The UK Prostate Nutritional Intervention StudyGut health, vitamin D & phytochemical support.
This national, ethically approved randomized controlled trial evaluated whether improving gut health, increasing vitamin D, and boosting phytochemical-rich food intake could influence prostate cancer progression, MRI changes, urinary symptoms, erectile function, inflammation, and markers of longevity.
A national RCT focused on nutrition, gut health and prostate cancer.
This study evaluated the impact of an intervention designed to improve gut health, increase vitamin D, and boost phytochemical-rich food intake among men with prostate cancer.
The trial was approved by the UK national Ethics committee with IRAS number 321309 and internationally registered under ISRCTN: 81939514. It started in September 2023 and completed in September 2024.
To improve gut health, the scientific committee chose the YourGutPlus+ blend because of its track record for safety and effectiveness.
The study aimed to evaluate whether the intervention could influence:
- PSA progression
- MRI changes over time
- Prostate-related urinary symptoms
- Erectile function
- Systemic inflammation markers
- Grip strength and other markers of longevity
Who participated and how the study was conducted.
Cohort
Men with histologically proven, early prostate cancer not taking androgen deprivation therapy, managed with active surveillance or watchful waiting.
Method
Following written informed consent, all 220 participating men were given the phytochemical-rich food supplement and asked to stop all other over-the-counter supplements.
Randomization
There was a double-blind, randomized 1:1 allocation of the probiotic supplement or placebo. Supplements were taken twice daily for four months.
Probiotic, vitamin D and phytochemical-rich food support.
The intervention combined YourGutPlus+ probiotic support with Your-Phyto phytochemical-rich food support, developed following a formal review of international scientific literature.
The probiotic capsule contains 10 billion colony forming units of five lactobacillus strains with built-in prebiotics.
The phytochemical-rich capsule contains whole foods with previously reported potential benefits for men with prostate cancer in epidemiological, laboratory and prospective studies.
- Combines six uniquely different food types
- Provides a wide spectrum of natural phytochemicals
- Combines both whole concentrates and extracts
- Measures and standardizes minimal levels of candidate phytochemicals
- Contains no foods with phytoestrogen properties
- Ingredients have a high safety profile
- Manufactured by a well-established UK manufacturer with high quality certification
- Evaluated in previous clinical trials and found to be safe and well-tolerated
Your-Phyto and YourGutPlus+ were central to the intervention.
Men who stopped other previous supplements and took YourGutPlus+ with Your-Phyto daily showed notable improvements across several prostate health and wellness measures.
Your-Phyto
A phytochemical-rich food supplement containing whole foods and targeted extracts selected following scientific review of international research.
YourGutPlus+
A probiotic capsule with 10 billion CFU of five lactobacillus strains and built-in prebiotics, selected by the scientific committee for gut health support.
Men taking YourGutPlus+ with Your-Phyto showed meaningful improvements.
Men who stopped all other previous supplements and took two capsules of YourGutPlus+ with two capsules of Your-Phyto each day had:
Slower rate of prostate cancer progression measured by PSA.
MRI disease correlated with PSA and stabilized or shrunk.
Improved prostate-related urinary symptoms.
Improvement in erectile function.
Reduced blood markers of systemic inflammation.
Enhanced grip strength and other markers of longevity.
Evidence for practical nutrition strategies in prostate cancer care.
This trial provides essential scientific evidence for health professionals and practical guidance for people with cancer who are interested in empowering themselves with effective strategies to improve well-being and help alleviate the toxicities of hormonal, radiotherapy or surgical treatments.
Study publications and lay summaries.
Abstract: PubMed
Read full paper: European Urology Oncology. Thomas R, Kenfield S, Williams M, Newton RU, Mitra A, Frazili Z. Oct 2025.
Reference: Thomas RJ, Kenfield SA, Williams M, Newton RU, Aldous J, Mitra A, Fazili Z. Increasing Phytochemical-rich Foods and Lactobacillus Probiotics in Men with Low-risk Prostate Cancer-A Randomised, Double-blind, Placebo-controlled Trial. Eur Urol Oncol. 2025 Oct 27:S2588-9311(25)00257-3. doi: 10.1016/j.euo.2025.10.003. Epub ahead of print. PMID: 41152052.
Lay Summary: Urology Today
Support prostate health, gut health and healthy aging.
Explore Your-Phyto and YourGutPlus+ to support your daily wellness routine with products connected to the UK Prostate Nutritional Intervention Study.